2/25/2009

[轉錄] 學習經驗也能遺傳給下一代

本文轉錄自生命科學線上

[文摘] 學習經驗也能遺傳給下一代

SkyOrggLee 報導




記憶和經驗有沒有辦法遺傳給下一代呢? 現在研究人員發現胎兒在母體懷孕期間,也有可能繼承母親了的學習經驗。

位於美國士波士頓的塔夫茨大學,Feig等人的研究發現,將青春期前的ras-grf knock out的母鼠,放置在複雜的環境(enriched environment, EE)下學習,可以增加神經細胞的生理過程(long term potentiation, LTP),而初生的幼鼠完全沒有經驗複雜的學習環境,相較於一般的幼鼠卻發現到LTP的增加。

這種特徵遺傳的想法最早是在19世紀拉馬克(Larmarck)提出,然而並未獲得重視,有別於現今遺傳學多採訥孟德爾遺傳學的理論,以DNA為遺傳物質做為媒介,遺傳給後代。

如果相似的現象也發生在人的身上,母親幼年的學習經驗將有可能留傳給下一代。

原始論文摘要:

J Neurosci. 2009 Feb 4;29(5):1496-502.

Transgenerational Rescue of a Genetic Defect in Long-Term Potentiation and Memory Formation by Juvenile Enrichment
Junko A. Arai,1 * Shaomin Li,1 * Dean M. Hartley,2 and Larry A. Feig1
1Sackler School of Biomedical Sciences and Departments of Biochemistry and Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, and 2Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612
Correspondence should be addressed to Larry A. Feig at the above address. Email: larry.feig@tufts.edu
The idea that qualities acquired from experience can be transmitted to future offspring has long been considered incompatible with current understanding of genetics. However, the recent documentation of non-Mendelian transgenerational inheritance makes such a "Lamarckian"-like phenomenon more plausible. Here, we demonstrate that exposure of 15-d-old mice to 2 weeks of an enriched environment (EE), that includes exposure to novel objects, elevated social interactions and voluntary exercise, enhances long-term potentiation (LTP) not only in these enriched mice but also in their future offspring through early adolescence, even if the offspring never experience EE. In both generations, LTP induction is augmented by a newly appearing cAMP/p38 MAP kinase-dependent signaling cascade. Strikingly, defective LTP and contextual fear conditioning memory normally associated with ras-grf knock-out mice are both masked in the offspring of enriched mutant parents. The transgenerational transmission of this effect occurs from the enriched mother to her offspring during embryogenesis. If a similar phenomenon occurs in humans, the effectiveness of one's memory during adolescence, particularly in those with defective cell signaling mechanisms that control memory, can be influenced by environmental stimulation experienced by one's mother during her youth.
Key words: synaptic plasticity; LTP; kinase; environmental; fear; memory formation

Received Oct. 17, 2008; revised Dec. 14, 2008; accepted Dec. 16, 2008.
Correspondence should be addressed to Larry A. Feig at the above address. Email: larry.feig@tufts.edu


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感想: 有趣的發現。呼~ 還好我青春期以前都還滿認真學習的。現在應該可以放鬆了吧~ (煙)

4 則留言:

  1. bardodo2/25/2009

    是阿
    我幼年時也很認真學習
    所以現在也可以放輕鬆一點囉
    真開心

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  2. 要是以後生了女兒,再逼她好好唸書,直到青春期。

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  3. 推薦個網站:
    http://esciencenews.com/

    記得前一陣子在那兒看過這則新聞,但因為是洋文兒,只看一下下就轉開了。嗯,找到了:
    http://esciencenews.com/articles/2009/02/03/do.you.know.what.your.mother.did.when.she.was.young

    嗯?老爹沒責任?

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  4. 不錯的網站。

    的確有謠傳指出兒子的智商受媽媽影響比較大。有一說是決定智商的基因都在X染色體上,所以男生的智商只由從媽媽來的X染色體決定。不過我一直沒找這個說法原始論文就是了,感覺唬爛的成份居多。

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